Endocrine Abstracts

Introduction: One of the most common side effects of glucocorticoid treatment is glucose intolerance and diabetes. Although glucocorticoids cause mainly postprandial hyperglycaemia the International Diabetes Federation, American Diabetes Association and The European League Against Rheumatism recommend to screen patients chronically treated with glucocorticoids by regularly determining fasting plasma glucose. Such an approach can lead to false negative results. Since pre-diabet...

Irisin (Ir), a recently identified adipomyokine, cleaved and secreted to the circulation from the FNDC5 protein in response to physical activity and some environmental conditions has been postulated to induces the differentiation of a subset of white adipocytes into brown fat and mediates the beneficial effects of exercise on metabolic homeostasis. Polycystic ovary syndrome (PCOS) – one of the most frequent endocrinopathies affecting women of child-bearing age is associat...

Polycystic ovary syndrome (PCOS) is a common endocrine abnormality connected not only with reproductive problems but also with impaired energy homeostasis leading to metabolic disorders including metabolic syndrome. Irisin (Ir), recently identified novel myokine, has been proposed to mediate some of the positive influence on metabolic disorders. The aim of our study was to search the relationship between Ir plasma concentration in PCOS in the context of metabolic disturbances....

The waist-to-height ratio (WHtR) has recently gained attention as an anthropometric index showing the highest predictive value for cardiometabolic risk in PCOS and healthy women. Central adiposity is the key driving force behind a constellation of inflammatation linked to insulin resistance, metabolic syndrome and cardiovascular diseases. PCOS is also considered to be linked to chronic inflammatory processes. Platelet count ratio/mean platelet volume (PLT/MPV), lymphocyte&#150...

Background: Amiodarone-induced thyrotoxicosis is sometimes extremely difficult to treat necessitating emergency thyroidectomy with perioperative risks including possible thyroid storm. We obtained near normalization of free T3 (FT3) by pulse Methylprednisolone prior to thyroidectomy for drug-resistant Amiodarone-induced thyrotoxicosis.Case Description: A 56 year old man (BMI 29.7 kg/m2), with history atrial flutter/fibrillation, episodes of fa...

Introduction: Type 1 diabetes mellitus is one of the most common chronic diseases in children. Precise knowledge of the pathogenesis of diabetes mellitus type 1 and its chronic complications is the enormous challenge in modern diabetology. In recent years, the role of leptin in the pathogenesis of microvascular diabetic complications has been highlighted.Aim: The aim of the study was to investigate serum leptin level and correlations between leptin level...

Objective: Diet and nutritional status during pregnancy are critical for the health of both mothers and the neonates. Women in twin pregnancies have higher metabolic needs compared to women in single pregnancies and it can be expected that they have higher risk of key vitamins and micronutrients deficiencies. However, very scarce data are currently available on this topic.Aim of the study and method: The main aim is to analyze the nutritional status of w...

Background: Vasopressin, secreted in equimolar amounts with copeptin, is implicated as a stimulus for ACTH secretion during dynamic tests, such as Glucagon Stimulation Test (GST) or Insulin Tolerance Test (ITT). Some individuals with intact ACTH-cortisol axis, demonstrate, however, a lack of further cortisol stimulation during GST. We have assessed whether failure of further ACTH-cortisol increase during GST may be associated with an inadequate vasopressin/copeptin release.</p...

Aim of the study: Estimation of the frequancy of diabetes and prediabetes in patients with adrenal incidentaloma (AI) without hormonal activity.Material and methods: The study comprised patients with AI without hormonal activity, verified by CT. The hormonal function of adrenal glands was determined according to the circadian rhythm of cortisol and/or dexametasone suppression test, ACTH, aldosterone, plasma renin activity, DHEAS, androstenedione, 17hydro...

Hyperandrogenism is a clinical condition characterized by excessive secretion of male sex hormones. An excess amount of androgens in women is manifested by symptoms of defeminization and masculinization. Hormonally active adrenal and ovarian tumors and non-tumor causes must be considered in the differential diagnosis. The authors describe the case of a 77-year-old patient who had hirsutism and reduction of the timbre of the voice. At the beginning she was suspected to have adr...